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In this work, the structural interactions between the LRG1 epitope and the Fab fragment of Magacizumab, a humanized function-blocking IgG4 against LRG1, are analysed, determining its specific binding mode and the key residues involved in LRG1 recognition

N-Acetylcysteine (NAC): A precursor to glutathione, NAC supports the body's production of this vital antioxidant, helping in detoxification, reducing inflammation, and promoting overall skin health

Indicated GSCs were pretreated with 50 M G3Ia or G3Ib for 30 min (n = 3), and then analyzed by immunoprecipitating and immunoblotting with the indicated antibody

Several studies have reported that autophagy prevents RGC death in glaucoma animal models such as optic nerve transection and IOP elevation 24,25

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