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The cell survival rate reached 88.24% after 48 h co-incubation at a high concentration of 200 g mL 1 , indicating an acceptable level of biocompatibility for potential clinical applications (Fig

Daridorexant has been approved by NICE (2023) for the treatment of long-term insomnia when all of the following apply: Cognitive behavioural therapy for insomnia is not available or has not been effective

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Further refinement and validation of the crystallographic data were performed using Collaborative Computational Project Number 4 and the Phenix software package (Phenix1.21) 60,61