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Under these conditions, the peptide remains stable for extended periods (typically 12-24 months from manufacture date)

The rate varies, but the trend becomes unmistakable

Taking into account all the published data of these studies, we noted a significant reduction in the ORR of patients undergoing combination (76) ( Figure 5 )

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Consequently, these anti-PD1-activated T cells were depleted by residual circulating anti-CD38, rendering the ICI treatment ineffective