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In summary, the beneficial effects of HBO on BBB integrity, collateral circulation, and angiogenesis, as elucidated in experimental models including subarachnoid hemorrhage and focal ischemia, may target shared pathways relevant to global cerebral injury following cardiac arrest, though validation in specific CA/CPR models remains essential

Most researchers report no noticeable potency issues at the 5-week mark, but conservative protocols suggest using the vial within 4 weeks and discarding any remainder