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6 Conclusion Oxidative stress, defined as an imbalance between the production of reactive oxygen species ROS and antioxidant defenses, plays a pivotal role in the pathogenesis of major diseases, including cardiovascular disorders, diabetes, cancer, and neurodegenerative conditions

Interestingly, fertility status and menstrual cycle phases do not seem to affect the variations of this biomarker [79,80,81,82, 136]

However, this does not invalidate other mechanisms such as changes in lysosomal pH during stress [54]

Too cold and your blood vessels constrict, shutting off the heat transfer