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Co-delivery of doxorubicin and hydroxychloroquine via chitosan/alginate nanoparticles for blocking autophagy and enhancing chemotherapy in breast cancer therapy

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Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]