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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

In receptor subtype profiling, laboratories can compare behavior across defined receptor complex constructs or cell backgrounds that vary receptor activity modifying protein composition

However, direct evidence for sex-specific changes in thyroid hormone (T3, T4, TSH) under the KD, is limited

doi: 10.2337/db13-0769 201 Artavanis-TsakonasSRandMDLakeRJ

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