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Liu Z, Liu W, Wang W, Ma Y, Wang Y, Drum DL et al

Ann Rev Physiol 42:97110

The characteristic neuropathology includes cerebral edema, atrophy, white matter abnormalities, and ventricular enlargement, progressing to seizures, coma, and cognitive impairment-clinical manifestations consistently exacerbated by concurrent acidosis or systemic inflammation (Longo et al