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2017b ) demonstrated that specific polyphenol metabolites, such as catechin derivatives and phenylvalerolactones, selectively accumulate in brain endothelial cells and neurons, where they mitigate oxidative damage

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This peptide helps improve insulin sensitivity, making it beneficial for individuals looking to optimize glucose utilization and support healthy blood sugar levels

To solve this paradigm, using repurposed compounds with known BBB penetrance provides promising therapeutic opportunities for GBM, with a special focus on the design of combinational drugs that specifically target cancer cells while minimizing damage to healthy cells