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doi:10.1200/JCO.2009.23.4823 28Sternberg CN, Davis ID, Mardiak J,

A medida que la NNMT se consolid como blanco teraputico potencial en la literatura preclnica, la investigacin medicinal busc inhibidores selectivos, permeables a membrana y de estructura sencilla que permitieran modular su actividad dentro de la clula

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We implemented the SQ infusion of OHCbl using a SQ catheter system together with a small, portable pump in four patients with cobalamin-related remethylation disorders in whom frequent IM injections were not or no longer feasible