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doi: 10.1056/NEJMra1004965 3 BustamanteMFGarcia-CarbonellRWhisenantKDGumaM

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Thus, targeting of the transporters expressed only at the BBB would be useful in terms of delivery of drugs with extracellular targets in the brain, while utilization of the transporters expressed at the BBB and cellular membrane of the brain parenchymal cells is essential for delivery of the drugs with intracellular targets

67,68 Hyperglycaemia and IR lead to a prothrombotic state in diabetic patients with changes in platelet numbers and activation, which leads to platelet hypersensitivity, coagulation disorders, and hypofibrinolysis