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The study conducted by (Shih et al., 2022)

While day 7 treatment response - measured as lymphoblast count in peripheral blood - is a well-defined, biologically straightforward phenotype with minimal confounding, more complex outcomes such as toxicities or relapse are influenced by numerous biological and environmental factors and require rigorous characterization

Lam JKW, Chow MYT, Zhang Y, Leung SWS

Autophagy is characterized by vesicles swallowing cytoplasmic proteins or organelles and further fusing with lysosomes for content degradation, which is essential for intracellular metabolic homeostasis and the renewal of certain organelles 35

However, despite the above discoveries, a solid link of ZIP6 to lymph node metastasis has not yet been entirely determined