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Expert Opinion on Therapeutic Patents, 14 (9), 1329-1344

Pathological pieces of evidence confirmed that patients with direct ARDS had localized damage to the lung epithelium, whereas patients with indirect ARDS had a systemic endothelial injury caused by diffuse vascular inflammation, where surfactant protein D and angiopoietin-2 were identified as specific plasma biomarkers of direct and indirect ARDS, respectively, both of which were prognostic of mortality [95]