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The butyrate depending activation of GPR109a enhances IL-18 excretion in epithelial cells, protecting the colon against inflammation and carcinogenesis (185)

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Preclinical studies in depression, schizophrenia, Alzheimers disease, and Parkinsons disease show superior exposure, target engagement, and behavioral or cognitive benefits versus free drugs, including photothermal/photodynamic and nanobody-based approaches