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Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

10.1111/j.1471-4159.2006.04172.x J

Current clinical practices in the general population, including in patients with diabetes, focus on reducing disease-promoting risk factors, such as hyperglycaemia, hyperlipidaemia and hypertension, but do not target the diabetes-induced mechanisms of atherosclerosis development and progression

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The red-light-activated phytochromes directly interact with PIFs and trigger rapid phosphorylation, ubiquitination and degradation of PIFs to release photomorphogenic development