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The homocysteine-lowering effect of folic acid may play a critical role in reducing the risk of NTD (58, 59)

doi: 10.3748/wjg.v13.i11.1711 30

NAC has also been used in combination with other potential neurotherapeutics including minocycline [20,21,22,23,24,25,26], topiramate [17], selenium [27], sulforaphane [28], levetiracetam, and gabapentin [29] and 2,4-disulfonyl alpha-phenyl tertiary butyl nitrone [30] with suggestion of synergy

It is known that macrophages sense the lack of glutamine and install a synthetic pathway for glutamine supply based on glutamine synthetase induction

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK