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Our study implicates that targeting the estrogen-dependent system x c , specifically SLC7A11 and SLC3A2, with IKE through induction of ferroptosis in ER+ breast cancer cells, should offer a new therapeutic option for patients with ER+ breast cancer, particularly those with endocrine resistance

(a,b) Adult male C3H/HeJ mice underwent unilateral surgical denervation by sciatic nerve cut at 10- to 13-weeks of age (N = 5 intact, 5 cut)

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Studies of functional magnetic resonance imaging further suggest an impairment of cerebral blood flow and/or oxygen metabolism, consistent with a disruption of the neurovascular and/or neurometabolic coupling in frontal areas of patients with schizophrenia both at rest and during activation [125, 126]

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