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In previous studies, TMAO, often used as a key metabolite in the study of microbial metabolome alterations in cardiovascular disease, has been shown to directly stimulate platelets by enhancing intracellular calcium release, among other pathways, causing platelet hyperreactivity, thereby increasing the risk of thrombus formation (50)

In the next sections, we will discuss the circulation of AFs in the human body and major AFs health consequences reported in the literature

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Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE

Therefore, a washout period is recommended when switching between Paxil and MAOIs to ensure that the drugs do not interact