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Compared with the broad consumer market of copper peptide skincare products, pharmaceutical applications have a smaller market capacity, making it difficult to justify the significant investment required for FDA drug approval

Our results are clinically relevant and consistent with clinical reports that the secretory capacity of -cell was diminished in first-degree relatives of individuals with T2DM even before the onset of obesity and insulin resistance 32

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EGEN-001, an IL-12-encoding plasmid formulated with PEG-PEI-cholesterol lipopolymers to enhance cellular uptake, is in a Phase II trial (NCT01118052) for persistent or recurrent epithelial ovarian cancer (197)

This is mechanistically different from opioid-induced constipation or magnesium deficiency