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Changes in SAM/SAH ratio and one-carbon cycle will thus modulate the activity of DNMTs and HMTs

Cell Factories 13 , 166177 (2014)

J Psychiatr Res 47:13961402

A selenium-deficient diet induced the expression of miR-138-5p, which in turn suppressed the expression of SELENOM that has antioxidant function, and caused mitochondrial dysfunction and apoptosis of chondrocytes 128

These findings suggest that UGCR may serve as a valuable biomarker for assessing CKD severity and may have potential utility for the monitoring disease progression, thus helping clinical risk stratification and ongoing management of feline patients