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Apparent hydroxyl radical production of peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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While some polyphenol-rich extracts, such as grape seed extract, have shown high tolerability in animal and short-term human studies, the safety of long-term, high-dose intake across a broad population spectrum remains to be confirmed (122, 123)

Note: When decoction or infusion is listed as an acceptable method of preparation, decoction concentrate or infusion concentrate is also allowed

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