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Elevated Ca 2+ levels in the mitochondrial matrix result in upregulation of ATP synthase and other components of the oxidative phosphorylation machinery in order to meet the increased ATP demand [133]

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Increasing antioxidant intake has been shown to deplete OS, accordingly, creating an energy crisis for preneoplastic cells, resulting in suppression of cell growth and activation of cell death pathways to impart chemopreventive effect during cancer progression pathway [279]

10.1016/j.jare.2022.01.004 141 WangX

If you experience nausea, try moving your dose to mid-morning or early afternoon to see if the timing makes a difference