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Furthermore, this combined treatment strategy augmented the expression of -H2AX and cleaved-caspase 3, indicative of enhanced DNA damage and apoptosis, effects partially reversible by NAC (Figs

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c) Relative fold change determined by quantitative real-time PCR (qRT-PCR) analysis of ULK, BECLIN1, ATG3, ATG7, ATG12 and LC3-II genes in EP and TMZ-treated resistant U87-R and non-resistant U87 cells