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doi: 10.1631/jzus.B2200590 40 VenancioVPCiprianoPAKimHAntunesLMTalcottSTMertens-TalcottSU

Thioredoxin is a relatively small regulatory protein serving an important redox function

oxidized cardiolipin not only triggers NLRP3 but also signals for mitophagy (mitochondrial autophagy) as a quality control

Similarly, in a STZ-induced diabetic hypertension rat model, ALT-711 combined with nifedipine produced superior outcomes compared to monotherapy by further lowering SBP and DBP, enhancing vasodilatory mediators (prostacyclin, NO), and reducing prepro-endothelin-1 expression [163]