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62 Additionally, H3K18la boosts the expression of the m 1 A eraser protein ALKBH3 and simultaneously attenuates tumor-suppressive promyelocytic leukemia protein (PML) condensates by removing m 1 A methylation from SP100A, driving tumorigenesis in ocular melanoma cells and orthotopic xenografts derived from ALKBH3-deficient 92.1 cells

This dual nature makes it prone to forming aggregates, clusters of peptide molecules that clump together in solution

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