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[167] "Up" debuted at number two on the US Billboard Hot 100 chart, marking the highest debut for a solo female rap song since Lauryn Hill's "Doo Wop (That Thing)" in 1998

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Thyrotropin-releasing hormone stimulation of adrenocorticotropin production by mouse pituitary tumor cells in culture: possible model for anomalous release of adrenocorticotropin by thyrotropin-releasing hormone in some patients with Cushing's disease and Nelson's syndrome