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Fernstrom, J

Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment

suis , cases of cross infections in humans have been documented in the past, but there is no known disease specifically associated with infections in humans (Beer, )

doi: 10.1111/jcmm.2018.22.issue-9 268 PassaroAVignaGBRomaniASanzJMCavicchioCBonaccorsiGet al

Plant Physiol 150:670683 Chen S, Vaghchhipawala Z, Li W, Asard H, Dickman MB (2004) Tomato phospholipid hydroperoxide glutathione peroxidase inhibits cell death induced by Bax and oxidative stresses in yeast and plants