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Those that are secondary to medication tend to cause more varied and less well-defined target lesions than when due to herpes simplex (antibiotics can be an exception) The most commonly associated medications include - the sulfa drugs, penicillins, tetracyclines, aromatic anticonvulsants (eg phenytoin and carbamazepine), thiabendazole, aspirin and other NSAID, furosemide and thiazide diuretics, phenothiazines, quinine, progestogens and omeprazole Pustular (figures 27-28) Chronology - symptoms occur within a few days of commencing the medication Pustules can be localised but are more often generalised and known as acute generalized exanthematous pustulosis (AGEP) Clinical features of AGEP - a generalised erythematous eruption with superficial desquamation