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These conditions may affect the nerves and muscles involved in the chewing process, leading to discomfort

Recently, Takeda and colleagues reported that mutant HSC70 nominally beneficial for modifying the SOD1ALS phenotypeparadoxically exacerbated symptoms in mice despite reducing SOD1 content (Takeda et al., 2025)

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The ability of methadone to blunt the euphoria produced by other opioids provides an additional stimulus for maintaining stability and entering into treatment among individuals dependent on opioids (90)