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11 Here, we show that stabilization of p53 and inhibition of CDK activity create unique cell states that exhibit distinct responses to cystine deprivation versus direct GPX4 inhibition

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Furthermore, reduction of PRL release and ERK1/2 phosphorylation mediated by DRD2 agonist were impaired after FLNA silencing, whereas DA-resistant prolactinomas lacking FLNA recovered responsiveness when transfected with FLNA ( Figure 3 Experiments in rat MMQ cells, a cell model of prolactinoma endogenously expressing functional DRD2 and FLNA show that FLNA is not only required for DRD2 targeting to the cell membrane but also protects DRD2 against lysosomal degradation, suggesting a role for FLNA in the control of DRD2 fate toward recycling processes or lysosomal degradation ( Beside a structural role in anchoring DRD2 to actin cytoskeleton and regulating receptor localization and stability, FLNA plays an additional functional role as scaffold for signaling molecules involved in DRD2 signal transduction