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General guidelines suggest individuals under 150 pounds may start with 50-75mg daily, those between 150 and 200 pounds typically use 75mg daily as a standard protocol, and individuals over 200 pounds may need 75-100mg daily for optimal effects

10.1016/S0165-5728(99)00187-3 284 VargasD

Likewise, inborn errors of metabolism that impair the upstream processing and trafficking of B 12 or folate lead to elevation of this metabolite, a condition collectively known as hyperhomocystinemia