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Studies show by inhibiting NNMT, the 5 amino compound prevents unnecessary methylation of nicotinamide, thus preserving NAD+ for energy metabolism

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Adding to the complexity is the overwhelming market of weight loss aids, many of which lack scientific validation or come with a host of unwanted side effects

Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype