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Complementarily, urolithin B (UB) suppresses immunosuppressive networks by inhibiting Treg activity and PD-L1 expression while upregulating human leukocyte antigen (HLA)-B and T-cell receptor (TCR) molecules to enhance antigen presentationeffectively mimicking DC vaccines (181), demanding advanced formulation strategies (e.g., nanoparticles, phospholipid complexes) to achieve therapeutic efficacy

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The use of a systems approach to increase NAD+ in human participants

Youwakim, J., Vallerand, D