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According to our previous practice, it has been demonstrated that local silencing of the locus coeruleus (LC, the main source of NA) by lidocaine could reverse BVA-induced analgesia in vincristine-dependent neuropathy (Li et al., One limitation of the current study is that it focused on the analgesic mechanism only in male rats

Since in most of the studies the participants were not masked to the intervention, and they reported the outcomes which were subjective, even if the assessors were blind to the intervention, the measurement of the outcome domain was at high risk of bias

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Thus, how to keep the balance of type 1/type 2 response in the development of TIbV against parasitic infection, is still a big problem