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Similarly, a nAb to respiratory syncytial virus (RSV) was shown to offer essentially complete protection in the cotton rat model following intranasal challenge at a serum neutralizing titre of ~1:380 135 , and this helped to guide the antibody dose used to protect at-risk infants by prophylactic administration 136,137

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PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier

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