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While ABCB1/Pgp substrates are neutral or cationic lipophilic compounds, ABCC1/MRP1 can transport lipophilic anions like leukotriene C4, glucuronate conjugates and sulfated bile acids

International journal of biomedical science : IJBS

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TRT is also not recommended if you have heart issues including: Uncontrolled heart failure A recent heart attack (within six months) Untreated high blood pressure Patients with other cardiac issues, if well managed, may be treated but require close cardiac monitoring, says Staheli TRT may also not be advised if you have sleep apnea