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461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS

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A more distinct separation was observed in the horizontal plane of PC 2 , with TPC and IPS loading in the first quadrant and EPS in the third quadrant