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Another study showed that Puerarin could block cisplatin-induced activation of TRPV1 and IP3R1, prevent intracellular calcium overload, and inhibit p65 to reduce excessive ROS production, thereby ameliorating cisplatin-induced ototoxicity and blocking apoptosis ( 3.1.2 Apigenin Apigenin is a natural flavonoid found in a variety of foods and beverages with antioxidant, anti-inflammatory and anti-tumour properties

Some prodrugs require specific enzymes or endogenous compounds for hydrolysis, such as the carboxylesterases including acetylcholinesterase, butyrylcholinesterase and arylesterase that are critically involved in the bioconversion of ester-based prodrugs into pharmacologically active forms ( 5.4 Combination drug therapy Combination therapies aim to improve curcumin bioavailability by inhibiting its inactivation and metabolism

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stenting with PDT versus stenting alone for unresectable CCA showed a marked survival benefit with the addition of PDT