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doi: 10.1186/s40348-016-0050-x 109 BieseckerLG

Among the amino acids (Thr, Leu, Phe, Trp, Ile, Val, Tyr residues) in proteins having strong tendency to form intra- or intermolecular -sheets, threonine is the only polar residue in the list of -sheet inducers, and should thus exert unique effects on interaction with its surroundings

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Although specific molecular mechanisms detailing the interaction between biochanin-A and NLRP3 are not well established in IPF, the compounds cardiac and neuroprotective effects have been associated with triggering the PI3K/Akt cascade and preventing the MAPK signaling cascade, indicating potential molecular crosstalk that could regulate the NLRP3 inflammasome

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