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In parallel, the dysregulation of TGF signaling ultimately contributes to Klotho deficiency and renal fibrosis by inducing the expression of various miRNAs (Morii et al., 2019)

When neurons are activated, they release ATP molecules that microglia can sense

For example, glucagon-like peptide-1 (GLP-1) drugs, such as semaglutide, are approved for diabetes and weight management sold as Ozempic and Wegovy

Alzheimers Dement 14 , 318329 (2018)

Our results, which are based on metabolite analyses of the tissues and plasma of mice as well as on cultivated cells, indicate that -GCS may also be responsible for the production of -Glu-Tau