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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

For instance, Alox15 knockout mice experience skin issues and increased inflammation [32]

We probed for OPA1 isoforms to investigate whether the ACT-insensitivity was related to OPA1-processing, which correlates with mitochondrial fragmentation

10.1093/jn/131.3.1010s J

Helps maintain healthy muscle function and blood pressure