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doi: 10.5935/1518-0557.20200043
Its complex pathogenesis involves dopaminergic neuron degeneration, -synuclein aggregation, neuroinflammation, oxidative stress, and mitochondrial dysfunction
Due to the positive health effects in the promotion and maintenance of health over the life course, the following observations shall be considered for the protection against moderate-to-severe COVID-19 infections during situations of severe health conditions (although they were not entirely present in the public mass media as general recommendation to aid in one's state of health or even to support vaccine efficacy): the risk for severe COVID-19 outcomes and the associated death was lower (i) in active people meeting the PA, sports, and exercise guidelines during the COVID-19 situation compared to inactive people (338, 352362), (ii) in people following dietary patterns characterized by high-quality choices, especially through healthy plant foods as best buys (339) compared to those did not prioritize their diet quality, and (iii) in people following vegetarian and vegan diets, which were associated with lower risk and severity of COVID-19 (reduction of up to 73%) compared to those following omnivorous diets (339, 340, 359367)
In addition, the metabolic process of casticin in vivo was also studied
