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In addition, SAM stabilizes CBS

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E.MontoyaM.FraileL.et al (2018)

Endothelin receptor antagonists Activation of the endothelin A receptor by endothelin-1 has been widely recognized as a key pathophysiological mechanism contributing to the onset and progression of CKD through multiple processes, including vasoconstriction, podocyte injury, inflammation, and fibrosis [173]