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While existing literature has established a link between alcohol use and alterations in brain morphology, many studies focus primarily on short-term exposure and acute effects

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Cuproptosis, a recently discovered form of programmed cell death, is triggered by the accumulation of copper ions and involves the binding of copper to lipoylated proteins in the tricarboxylic acid (TCA) cycle, leading to protein aggregation and cellular demise [11,12,13]

Interestingly, no differences were found between the drug-treated and sham-treated groups, with regards to locomotor activity, as assessed by the chimney test and the tilted plane test