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It works by down-regulating pro-inflammatory cytokines and suppressing NF-B signaling pathways

How Ibuprofen (Advil/Motrin) Works Ibuprofen is a Non-Steroidal Anti-Inflammatory Drug (NSAID)

Results Administration of exogenous melatonin alleviates allergic airways disease severity in allergen-exposed mice Given the growing evidence linking circadian disruption to increased severity of allergic asthma ( Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously ( Figure 1A )