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According to the prevailing hypothesis about the mechanisms of lead toxicity, Pb(II) oxidizes GSH, leading to increased levels of free radicals [95]

Nonetheless, natural vitamin K forms (e.g., phylloquinone) achieve brain concentrations only ~2% of plasma levels, substantially below the threshold required for neuronal ferroptosis inhibition

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Lim W, Yang C, Bazer FW, Song G (2016) Luteolin inhibits proliferation and induces apoptosis of human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein activity