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The missing strand is provided by 5, which comprises in its folded domain the seven -strands of a conventional C L domain and, in a sequence extension outside the folded domain, the additional -strand missing in VpreB 3

But it still provides the same thyroid-balancing, antibody-lowering benefits regardless of whatever condition you may have

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Mazur P

Crit Rev Oncol Hematol 59(1):4050 Casparini G et al (2005) Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and other questions