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186 With respect to the specificity of Cu chelators, the use of trientine has been shown to inhibit the expression of IL-8 and exhibits anti-tumor effects in hepatocellular carcinoma

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Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders

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This doesn't necessarily mean that all vegetarians need B12 injections, but it is advisable for vegans and vegetarians be mindful of their B12 intake to ensure they are getting sufficient levels of this vital nutrient