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These studies and others like them demonstrate the thioredoxin system plays a critical role in the maintenance of the S-nitroso proteome by two distinct mechanisms: (1) reduced Trx denitrosates low-molecular weight and protein S-nitrosothiols

Mitchell KG, Parra ER, Nelson DB, Vaporciyan AA, Hofstetter WL, Mehran RJ, Swisher SG, Rice DC, Sepesi B, Walsh GL, Zhang J, Behrens C, Kalhor N, Weissferdt A, Moran CA, Wistuba II, Fujimoto J, Roth JA, Antonoff MB

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This mechanism establishes a molecular basis for immune escape of tumor cells ( V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) promotes cholesterol uptake in colorectal cancer cells by facilitating endosome maturation through rabaptin-5 GDP/GTP exchange factor (RABGEF1)

Controversies exist over the TP53 mutation status dependencies of APR-246