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The majority of patients had a single lesion (84.6%) and were Barcelona Clinic Liver Cancer (BCLC) Grade 0/A at time of diagnosis

The effectiveness of D-methionine in this connection brings back to mind the early studies of Rose who used DL-methionine in his early balance studies which led to the RDA recommendations, again suggesting a significant role for the SAA, beyond that of protein synthesis

Pharmacology Biochemistry and Behavior, 77 (2), 399-404

Appropriate Clinical Use Best suited for stress-related insomnia, anxiety-driven sleep disruption, burnout with poor recovery, performance optimization requiring stress resilience and deep sleep, or comprehensive nervous system support

This highlights the importance of identifying preventive strategies to mitigate the risks associated with the use of these agents (Table 1)